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KMID : 0351619670080010132
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Kyungpook Medical Journal
1967 Volume.8 No. 1 p.132 ~ p.139
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Some Physiologic Changes in the Hypothernic Dog
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Abstract
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Liver function studies were carried out in 20 hypothermic dogs. Measurements were performed following 2 hours´ maintenance of body temperacure at 20℃.
The results were compared with those of precooling conditions.
1. While cooling and rewarming, no significant changes were seen in plasma total protein, albumin, globulin and A/G ratio.
2. Though S-GOT and S-GPT activities remained on the same level with controls, the alkaline phosphatase activity increased following the 2 hours of 20℃, and did not return to the precooling level even when rewarmed.
3. No significant changes were seen in totoal bilirubin, thymol turbidity test and cephalin cholesterol flocculation test during hypothermia.
4. When the bodies were cooled, BSP dye showed a remarkable retention : in 5 cases, 51.9% retained 45 minutes following the injection, which is roughly 15.7 times the normothermic value of 3.3%.
5. Galactose tolerance test was done in each five dogs of normothermic and hypothermic dogs. The galactose retention rates in the blood of the cooled animals at 20℃ were 58.4% and 21.5% after 20 and 40 minutes respectively, while in the control, they were 22.1% and 11.9%. This active retention ratio indicated that synthesis of galactose to glycogen in the hypothermic liver tended to be retarded.
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